Long-term Efficacy of Narivent® in the Treatment of Nasal Congestion
Valerio Damiani, Angelo Camaioni, Claudio Viti, Giulia Schillani, Francesca Foltran, Antonella Silvia Scire, Giada Morpurgo, Dario Gregori
Identifiers and Pagination:Year: 2012
First Page: 73
Last Page: 79
Publisher Id: TOMDJ-4-73
Article History:Received Date: 8/8/2012
Revision Received Date: 15/08/2012
Acceptance Date: 17/08/2012
Electronic publication date: 20/9/2012
Collection year: 2012
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Rationale and aim:
Nasal congestion is a common symptom in allergic and non-allergic rhinitis, rhinosinusitis and nasal polyposis. Although various pharmacotherapy options exist, no agent is universally efficacious. The aim of this study was to evaluate the clinical effectiveness efficacy of Narivent®, which is an osmotically acting medical device with anti-oedematous and anti-inflammatory effects, in a long-term (30 days) treatment.
A single-centre prospective study with a pre-post design was conducted with consecutive enrolment in an Italian Otolaryngology Department of 56 both genders patients with persistent nasal congestion.
Patients received 2 puffs of Narivent® into each nostril 2 times a day over the course of 4 weeks. The severity of symptoms was assessed subjectively as measured by a 0 to 10 visual analogue scale (VAS) and the presence/absence of symptoms and signs. Differences in subjective and objective severity measures before and after treatment were compared using Paired-Sample Wilcoxon Signed Rank Test.
A significant improvement after treatment (p<0.001) has been recorded for the main subjective symptoms and objective signs (overall symptom burden, nasal congestion, cephalea, rhinorrhea, hyposmia, turbinates hypertrophy, mucosa status).
Study results confirm the efficacy of Narivent® in treating nasal congestion over a 4 weeks period.