Economic Impact of Treatments for Controlling Symptoms Associated with Rhinitis: an Evaluation of Narivent® vs Standard Therapy

Valerio Damiani1, Dilyana Vicheva2, Angelo Camaioni1, Claudio Viti1, Giulia Schillani3, Giada Morpurgo4, Antonella Silvia Scire4, Dario Gregori5, *
1 ENT Department San Giovanni Addolorata Hospital, Rome, Italy
2 Bulgarian Rhinologic Society, Department of Otorhinolaryngology, Medical University, Plovdiv, Bulgaria
3 Department of Life Sciences,University of Trieste, Italy
4 Zeta Research Srl, Trieste, Italy
5 Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy

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© 2012 Damiani et al.;

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Correspondence: * Address correspondence to this author at the Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular Sciences, Via Loredan, 18, 35121 Padova – Italy. Tel: +39 049 8275384; Fax: +39 02 700445089; E-mail:


Rationale and aim:

Upper airway disorders, like allergic and non-allergic rhinitis, are common nasal conditions affecting millions of individuals worldwide. The prevalence of allergic rhinitis (AR), in particular, has been increasing in the last decades. The pervasiveness of this disorder therefore imposes a large burden both on individual patients and the society. A wide range of drugs exists for symptomatic treatment of rhinitis, such as corticosteroids, decongestants, and antihistamines, but standard therapies are often associated with several side effects. A new class of medical devices, based on bio-mechanically innovative triggers, has been proven to have a good clinical effectiveness with lower adverse reactions, particularly over prolonged administration periods.

The present study aims at evaluating the economic impact of rhinitis, with respect to direct and indirect costs, and analysing the use of the medical device Narivent® compared to standard therapies to manage the symptoms of this illness.


Via a Monte Carlo simulation study, data on disease prevalence, drug prescription and cost of both the specific therapeutic approach and the adverse events treatment will be combined to provide an estimate of the overall cost of the pharmacotherapy as compared with Narivent®


Lowering the impact of adverse reactions related to standard therapy through the use of novel therapeutic approaches like Narivent®, might reduce the overall burden of rhinitis by about 5 billion per year.


The use of the medical device Narivent®, as an alternative approach to manage symptoms associated with rhinitis, may contribute to bring down its costs by about 3.5% yearly as compared to the standard therapy.

Keywords: burden of rhinitis, cost impact analysis, allergic rhinitis costs.